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Constipation in B12 deficiency is primarily neurogenic, due to autonomic and enteric neuropathy causing slow gut motility • Constipation may precede anemia • Often improves after B12 replacement • Think of B12
Semax has BDNF-boosting effects in animal models (Dolotov et al., 2006), but no randomized controlled trial has tested it for ADHD in humans
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