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Avoid mixing GHK-Cu with acidic solutions such as vitamin C or AHA/BHA serums for topical use
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Meanwhile, hypoxia activates the HIF-1α/PDK4 axis, which inhibits PDH activity and elevates mitochondrial membrane potential(MMP), suppressing the TCA cycle while enhancing glycolysis and lactate production, ultimately driving VSMC cell cycle progression and proliferation [86]
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