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doi: 10.3389/fphar.2024.1491249 Received 04 September 2024 Accepted 14 November 2024 Published 02 December 2024 Volume 15 - 2024 Edited by Anna Maria Giudetti, University of Salento, Italy Reviewed by Daniele Vergara, University of Salento, Italy Azza Awad, Al-Azhar University, Egypt Updates Copyright © 2024 Mahmoud, Elshazly, El-shaarawy, Zaitone, Aldahish, Ahmed, Fawzy, Aloyouni, Abed, Saeedi and El-Sayed
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Research has characterised GHK-Cu’s angiogenic biology in endothelial cell tube formation assays, aortic ring sprouting models, and in vivo wound healing and tissue repair paradigms — examining VEGF and FGF-2 upregulation kinetics, endothelial cell proliferation and migration responses, tube formation amplitude relative to positive angiogenesis controls, and the contribution of GHK-Cu-driven angiogenesis to the overall tissue repair and wound healing response
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