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Size:0.68oz / 20ml
2 CYP450s Mediated Metabolic Activation of Natural Products Leading to Toxicity 2.1 Metabolic Activation of Pyrrolizidine Alkaloids Leading to Hepatotoxicity, Phototoxicity and Pulmonary Toxicity Pyrrolizidine alkaloids (PAs) are the class of common toxic natural products widely distributed in over 600 herbals around the world, and are found in approximately 3% of the world’s flowering plants (Robertson and Stevens, 2017)
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