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Apart from mutations, other significant factors accounting for α-synuclein fibrillation are changes in pH of the microenvironment (Frey et al., 2024), presence of other metal ions temperature (Puspita et al., 2017), phosphorylation (Ghanem et al., 2022
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c) In a clinical trial involving patients with osteoporosis, BPC-157 supplementation led to improvements in bone density and calcium metabolism markers, indicating its potential as an adjunctive therapy in calcium imbalance disorders
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