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In addition to glucose, microglia utilize glutamine as an energy substrate, facilitated by the high expression of glutamine transporters SLC1A5 and SLC38A1 (Liu et al., 2018)
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The investigation of the molecular mechanisms underlying these effects showed that miR-486-5p acts as a tumor suppressor by targeting the transcription factor PLAG1 Like Zinc Finger 2 (PLAGL2) which regulates IGF2 and β-catenin expression, thus resulting in the inhibition of cell proliferation and invasion (101)