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Some patients with severe forms of the disease lose all of their scalp hair, eyelashes, eyebrows (see Columbus microblading or Guybrows), and all the rest of their body hair as well, a condition known as alopecia universalis
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Furthermore, the requirement for stringent downstream purification to ensure complete enzyme removal adds to the overall process complexity and remains a primary technical constraint for large-scale production (Morgan et al., 2022
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