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To test this hypothesis, we used our preclinical xenograft model with the human SCLC cell line H209, which was derived from an untreated patient and asked whether DKFZ-608 could prevent tumor recurrence following complete remission after standard chemotherapy with cisplatin/etoposide

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SLC7A11 Cystine transporter solute carrier family 7 member 11 (SLC7A11) encodes the light chain subunit xCT of system x c − and promotes GSH synthesis by mediating Cys uptake and Glu release [51, 71]