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Furthermore, because some NAPQI is created regardless of the function of the other 2 pathways, failure in the glutathione-dependent pathway is expected to result in the accumulation of NAPQI and subsequent toxicity, even if the other 2 pathways are functional

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The level of ALP was also significantly increased in the skin tissues of the B50, B100 and Minoxidil-treated groups compared with the control and B + IWR-1 groups (Fig