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In addition, enzymes, such as xanthine oxidase, NADPH oxidase (NOX), and myeloperoxidase (MPO), become overtly hyperactive during reperfusion and significantly contribute to the production of ROS (Sasaki and Joh, 2007
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Since then, numerous experiments have been performed on riboflavin biosynthesis optimization via microbial strain improvement using biological, genetic, and bioinformatics approaches